He played an Armenian on Kung Fu, an Italian on Banacek, a Native American on Gunsmoke and a Hawaiian on Hawaii Five-O. He moved to Los Angeles, made his onscreen debut in a nonspeaking role as a jewelry fence on a 1969 episode of It Takes a Thief and then appeared on other shows like Medical Center, The High Chaparral, Mod Squad and The Flying Nun. Eventually, he worked with the National Shakespeare Company and in the New York Shakespeare Festival, appeared in off-Broadway productions and, in one brief brush with Broadway, was a standby in The Ninety Day Mistress in 1967. Sierra was with a friend who was auditioning for an acting class when the teacher invited him to try some improvisation and was impressed. “It was hard to study to be a priest during the day and go out and plan gang warfare at night!” “I wasn’t going to be a priest!” he said. He attended the Cathedral College of the Immaculate Conception, a Brooklyn prep school for boys aiming for the priesthood. The neighborhood was rough, and Sierra flirted with gang life as a teen and once was knifed. “Everybody lived together - grandmother, grandfather, aunt, two uncles, mother, father … gradually everyone went their way.” “When I was a baby, we were a typical Puerto Rican family,” he said. 25, 1937, Sierra was raised by his aunt after his parents abandoned him when he was 6. “We had been together six years, and her death leaves me feeling guilty as well as feeling the grief.”īorn on Jan. “We were separated at her wish,” Sierra said in 1978. Only two weeks into shooting the series, his second wife, Susan, committed suicide. Hudson Street debuted in 1977 but was canceled after six episodes. Those are the kinds of things we show on Barney Miller.”Ĭhano was written out of the series at the end of the second season so that Sierra could star in a new sitcom from Barney Miller creator Danny Arnold, this one set in a frenetic New York emergency room. You never see the frustrations of police work or the kind of joking that goes on among real policemen. Everything is always under control on that show. “The people in the show have real problems. “I think Barney Miller is much more real than any other cop show,” Sierra said in an interview for the 1976 book TV Talk 2: Exploring TV Territory. His colleagues believe he deserves a commendation, but a distraught Chano feels otherwise, and he breaks down and cries. Nowhere was this better displayed than in the 1975 episode “The Hero,” in which his character kills two suspects while preventing a robbery. “Julio Fuentes? That don’t sound like no name - that sounds like somethin’ you get from drinkin’ their water.”Īfter he left that series, Sierra played one of the original detectives working out of the diverse 12th Precinct in Greenwich Village on ABC’s Barney Miller, joining Hal Linden, Abe Vigoda, Ron Glass, Max Gail and Jack Soo when the show premiered in 1975.Ī proud Puerto Rican New Yorker, Sierra’s Chano was dedicated and dauntless, a cop who emotionally invested himself in his work. “You know what the Puerto Rican national anthem is? ‘We’ll take Manhattan, the Bronx and Staten Island too …’ ” Fred complains to his son, Lamont (Demond Wilson), when he learns who’s moving in next door. Introduced in the second-season episode “The Puerto Ricans Are Coming,” Julio was an easy target for the crotchety, bigoted Fred (Redd Foxx). His career breakthrough came in 1972 when he was cast as the easygoing Julio, junkman Fred Sanford’s Puerto Rican neighbor, on NBC’s Sanford and Son, developed by All in the Family creators Bud Yorkin and Norman Lear. Jacklyn Zeman, Actress Who Played Bobbie Spencer on 'General Hospital,' Dies at 70
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There are no deliveries on Saturdays, Sundays or Bank Holidays. These times are an estimation, not a guarantee. These delivery times are the maximum delivery periods that a purchase can take to reach our customers. School is stressful for shy, quiet Emmie Katie, meanwhile, is breezily popular, confident, and beautiful. Standard Delivery: Free (2-4 working days) Express Delivery: £2.49 (reduced rate, 1-2 working days)Įxpress Delivery: Free (1-2 working days) First theres our narrator, Emmie, whos shy. Standard Delivery: £2.99 (2-4 working days) Express Delivery: £4.99 (1-2 working days) In Terri Libensons Invisible Emmie, we get a glimpse into the lives of two very different middle school girls. If any items are missing from your delivery, please allow 2 working days for the rest of your order to arrive before contacting us at of our books are 100% brand new, unread and purchased directly from the publishers in bulk allowing us to pass the huge savings on to you! Items from our extended range section are dispatched separately. So this is one thats been very popular, selling lots of its called Invisible Emmie, and its by Terri. We sometimes split orders between multiple parcels. And Sex Ed Rescue is that channel where I review books. Please note orders are only processed Monday-Friday. The orders go into our warehouse to be picked, packed and consolidated into one parcel where appropriate. Invisible Emmie centers around one specific day at school and how a note that Emmie drew about a boy causes the lives of Emmie and Katie to intersect. Ruby is a little awkward, not a joiner, and loves to write poetry while Mia is type A, popular (ish), and wants to be class president. We aim to process and dispatch our orders within 24 hours. Remarkably Ruby Terri Libenson 4.22 1,190 ratings156 reviews Pride. Quite a few things aren’t on Mozilla’s list - such as updating 3rd party libraries very quickly (took a while for ICU to get updated to 55.1 from 52.1) for example. I’m going to go through and strip out things such as this. Waterfox doesn’t include either and won’t (unless users really want them). A lot of new Firefox “features” are against what Mozilla are about, such as integrating Pocket or the inclusion of HTML5 EME. And that was fine, but until that happened WF offered users an alternative while waiting for it. Also as another example, back before Firefox for Mac had support for MP4 files, Waterfox implemented support for them utilising GStreamer (Mozilla wanted a native approach). Some things Mozilla won’t implement, such as support for WebP images, Waterfox has implemented. But I don’t really, so I can enable these features (mostly talking about HTML5 features that work here). This makes sense, as Mozilla have other things to prioritize. Once I get WF43.0 all finished up, I’ll make sure to put some benchmarks together and hopefully get some users to test as well.Ī lot of features lie dormant in Firefox, either due to being forgotten or just leaving it for later. For example on my laptop with an i7-4720HQ, Waterfox 40.1.0 runs about ~20% faster in the JetStream (successor to SunSpider) benchmark compared to Firefox 42.0 64-Bit (and Waterfox’ main focus is speed ) ). Intel’s C++ compiler still generates faster code than Visual C++ does and on powerful systems it makes a big difference. The browser development started when there was no 64bit version of Firefox was available, So why people are using the Waterfox when Firefox 64 bit version is available ? The developer answers it as follows Memory usage of the browsers - Lightest browser Earlier we compared the memory usage of the browsers which you can read below Ashwin suggested this browser and I must say that this one is better than Firefox (at least for me). Waterfox registry entries to not use the same as Firefox (Windows Only)įull support for Windows XP (including WebGL, may have to disable Hardware Acceleration)įirefox was hanging on my system, and I wanted to find better browser which is light and faster. Removal of all Mozilla Data Reporting services (properly) Removal of Encrypted Media Extensions (DRM) The latest version of the browser have the following changes The development started on 2011 and now the latest version currently available is 43.0.1 which released last week based on the 43.0.3 Firefox. Waterfox is designed especially for the 64bit operating system. Waterfox is a browser based on Firefox developed by Alex Kontos. The game currently features three challenging game modes: Join our VIBRANT ESPORT SCENE and gain a reputation for YOU and your team. You are strong by yourself but stronger as a team.Ĭritical Ops League expands the world of esports onto mobile platforms. Host private matches and organize tournaments to win prizes. Go SOCIAL! Build your dream team and invite your friends to join your clan. While playing, you will learn new mechanics and gain knowledge, allowing you to evolve as a player. Competitive ranked games pit you against other similarly skilled operatives. Offering no in-app purchases that give competitive advantages, we guarantee a FAIR-TO-PLAY scene! Master a variety of weapons and improve your shooting skills by competing in intense PvP gameplay. The outcome is determined by your skills and your strategy. When duty calls, you must answer! Will you fight as a member of Coalition or The Breach? Battle it out alongside your band of brothers or lead an individual scoreboard. Are you ready for the challenge?Ĭritical Ops is a first-person shooter that features competitive combat through beautifully crafted maps and challenging game modes. Experience action, where fast reflexes and TACTICAL skills are essential to success. A ton of free weapons are provided, as well as costumes.Ĭritical Ops is a 3D MULTIPLAYER FPS designed exclusively for mobile. Great visuals and various graphics! And without any lag. Team up with your friends to play together. Engage in the thrilling game with 1 MILLION daily players. 5v5 shooting online.Ī giant 3D FPS action shooting game is waiting for you! Mobile shooter setting the trend for action PVP gun games. Most studies report the interaction with cytokine TNFα and fibroblast growth factor 2 ( FGF2) (Fig. Of the 143 cytokines present in this database, 65 were identified to interact with ECs. To review established interactions, we used immuneXpresso, a text mining engine that extracts directional cell-cytokine interactions from PubMed abstracts 26. Mapping cytokine-endothelial interactionsĪlthough vascular inflammation is orchestrated by cytokines that activate the endothelium, knowledge on endothelial-cytokine interactions at the system level is limited. This study reveals system-wide adaptive EC inflammatory states, emphasizing the role of EC-cytokine interactions in inflammatory pathogenesis and reiterating ECs as an adaptive player in inflammation. Combining multiple omics levels, we dissected the molecular basis of these inflammatory states from signaling (phosphoproteome) to mRNA transcription (transcriptome), protein regulation (proteome) and protein secretion (secretome). Moreover, combined stimulation of TNFα and IFNγ resulted in a synergetic EC response. However, upon stimulation with an unbiased cytokine library, we observed predominantly unique inflammatory states for TNFα and IFNγ. We show that ECs express the receptor-repertoire to facilitate various cytokine signals. Therefore, in this study, we set out to dissect the molecular signatures of endothelial-cytokine responses, employing blood outgrowth endothelial cells (BOECs), also known as endothelial colony forming cells, as our source of ECs because of their extensive, robust expansion, expression of mature vascular EC markers and ability to be isolated from adult donors 24, 25. Although underlying mechanisms have been proposed, a system-wide EC response has not been characterized. Moreover, synergism between cytokines such as TNFα and interferon-gamma (IFNy) has been observed in ECs and linked to detrimental effects in inflammatory disorders 20, 21, 22, 23. This endothelial dysfunction is implicated in several multi-facetted inflammatory diseases, including transfusion related acute lung injury, sepsis, rheumatoid arthritis, acute respiratory distress syndrome (ARDS), eye vasculopathies, chronic kidney disease and COVID-19 10, 11, 12, 13, 14, 15, 16, 17, 18, 19.Īlthough both endothelial homeostasis and cytokines are deregulated in these diseases, the molecular basis which orchestrates adaptive endothelial-cytokine interactions is mostly confined to research on tumor necrosis factor-alpha (TNFα). However, although ECs carry these immune-modulating properties and are among the first cells to come into contact with pathogens, they are rarely mentioned in immune cell networks 7, 8, 9.ĭeregulation of EC homeostasis can result in over-inflammatory or hyper-coagulation states of the endothelium. In addition to the transmigration of immune cells, ECs have several immunomodulatory capacities such as antigen presentation and cytokine secretion 5, 6. For their role in this adaptive synapse, ECs are well-equipped to sense environmental cues, such as mechanical stress, hormones (e.g., vasopressin, histamine), cells (e.g., neutrophils, monocytes, platelets) and other external stimuli (e.g., thrombin, cytokines) 2, 3, 4, 5. Moreover, ECs are crucial gatekeepers controlling the trafficking of immune cells into and out of tissues during inflammation. Apart from facilitating oxygen, nutrient, and waste product exchange, ECs control hemostasis by attracting platelets to seal breaches in the vascular walls during primary hemostasis 1. This resource describes the intricate molecular mechanisms that are at the basis of endothelial inflammation and supports the adaptive immunomodulatory role of the endothelium in host defense and vascular inflammation.Įndothelial cells (ECs) line the inside of our blood vessels and form a dynamic interface between blood and surrounding tissues. Synergy resulted in cooperative activation of transcript induction. We employed a multi-omics approach to dissect these inflammatory states, combining (phospho-) proteome, transcriptome and secretome and found, depending on the stimulus, a wide-array of altered immune-modulating processes, including complement proteins, MHC complexes and distinct secretory cytokines. Notably, combined TNFα + IFNγ stimulation induced an additional synergetic inflammatory signature. Applying an unbiased cytokine library, we determined that TNFα and IFNγ induced the largest EC response resulting in distinct proteomic inflammatory signatures. Here, we aim to dissect the system-wide molecular mechanisms of inflammatory endothelial-cytokine responses. Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular inflammation. Import your video file from iMovie into Keynote.Make a square presentation at 1080x1080.Then, export your video file and open Keynote.Here’s how you can get started on a desktop: From all of my digging around on the Internet, it seems to be the only totally free workaround I’ve found for creating square videos on your desktop. You may know and love it as a presentation tool, but haven’t ever dared to use it as a video editor. So, what’s a video marketer to do?Įnter: Keynote. However, it doesn’t support editing in different aspect ratios. If you’re on a desktop, iMovie is the standard, free video editor that most folks use. Upload your video to Facebook or Instagram, and you’re good to go!Īnother bonus? This app lets you try out a bunch of different aspect ratios in addition to the 1:1 ratio, making it super-simple to toggle between one another. Then, click the export icon, let it render, and save it to your camera roll. The simplest, most straight-forward cropping app I’ve found so far is an app called, well … Video Crop! This app felt the most user-friendly - simply import your video, select the 1:1 square aspect ratio, and move the selection to your desired crop point. If you’re shooting and posting square videos on your phone, there are a ton of apps out there that can help you crop your video into a square format. And luckily, in this post, we’ll walk you through exactly how to do it. So, how do you actually make a square video? Whether you’re on a computer or on your phone, you’ll need software to crop your video to a 1:1 square aspect ratio. And according to the folks at Buffer, over 90% of people use their phones to engage with social platforms like Facebook, so it’s crucial to optimize for mobile users! The more real estate on a user’s screen your content occupies, the better. Because square video takes up more real estate on the viewer’s feed than landscape video does, channels like Facebook and Instagram are perfect playgrounds for square video. It may sound surprising, but square video has actually become a lot more popular as of late (and for good reason). Horizontal, vertical, and now square video. As a result, the development team had the idea to change the Crates for Blueprints and Keys for Credits. Later on, since the Crates were leaving the drop pool, keys had no meaning in your inventory. At the same time, you had the option to trade keys for other items with another player. So if you had a lot of Crates wandering around, you had to obtain these keys to test your luck. Those had the power to open all types of Crates from the game. First of all, you had the “Keys,” which required real money from your wallet. Unlike the video games that try to emulate the “mobile” way of earning multiple in-game currencies, in the Rocket League, everything is simple. In this article, we’ll give you different tips to spend Rocket League Credits accordingly and take full advantage of this virtual good in your account. In exchange, you’ll see more updates and amazing cosmetics that can to increase your enjoyment of the game even more. You can show your appreciation and give motivation to the developers by buying credits from time to time. If you like game for more than one session throughout the week, you’ll probably wish to keep it going. Furthermore, since almost all the good looking items are just cosmetics, so you won’t get advantages if you consistently support the developers.Īlso Read: Rocket League Ranks – RL Ranking System & MMR Explained But since it will turn to the “free to play” business model, soon you will be able to play the game without spending a dime. In Rocket League, you pretty much have all the above. Moreover, there are the battle passes and microtransactions that let you obtain in-game items in exchange for real money. Secondly, you have things like the season passes, DLCs, and expansions that give a little more content in the game. First of all, you have a simple pay to play model where you simply have to purchase the game. Time and time again, we keep seeing different online or “live-service” games in the market that use techniques to keep the servers running. Daughters of Mars adds female units to the battlefield for some factions, which can fill some niches in those factions (Lusitani Swordswomen are one of my favourite units.) Beasts of War adds animal based units, which can be fun and I believe Suebi players specifically like the Wolf Warriors I think it adds. NOTE: This is the only DLC to not add anything to the Grand Campaign (the main Rome II campaign) nor custom/multiplayer battles (though you can play the Wrath of Sparta campaign in multiplayer campaign modes.)Īdd units funnily enough. But some people really don't like it, so it's really up to you. If you really like Hoplite warfare and Greek history then it's meant to be a lot of fun. WRATH OF SPARTA is set much earlier than even Rome II's start. The Campaigns are each fought on new maps, which provide a much more detailed environment and allows for all sorts of options you can't do in the main campaign.ĬAESAR IN GAUL and HANNIBAL AT THE GATES both have focused campaigns in a shorter time span (so each turn is only a few weeks, rather than a year as is the case with Rome II.)Įach offer 3 new factions for the main game, some of which also feature in the DLC campaign, including two of my personal favourites Nervii (in Caesar, Belgian warriors who like to ambush) and Lusitani (in Hannibal, a faction that's low on armour, but high on javelins and guerilla warfare.) These cost a little more, but you generally get 3 new factions AND a campaign that can have it's own mechanics and challenges. Some also offer different playstyles (Nomadic Tribes are basically all Cavalry, Black Seas have hybrid rosters so a mix of units, Pirates & Raiders can hire mercenaries a lot cheaper, but their upkeep is also increased, and Greek States use Hoplites a lot.) They each have different starting positions in campaign, unique traits and units, some have their own culture. Different people will rate them differently. These each add 3 new factions that you can play. I personally feel that they are all value for money based on the enjoyment I've got out of them, and when they're on sale even better.Īs for the DLCs I'll split them into categories: I have all the DLCs (except Blood & Gore, as it doesn't interest me.) Really they depend on what you're after. But it's one of my favourite Total War campaigns in any game, so I rate it pretty highliy. Note: I haven't updated this for Empire Divided or Power & Politics yet. Even if you don't own the DLC, the factions and units will still appear in the Grand Campaign for the AI with their full rosters, traits etc, because they were patched into everyone's game for the AI to use when the DLC was released. It's important to note that with DLC that adds factions or units to the Grand Campaign (the 4 Culture Packs, 2 of the Campaign Packs and the 2 Unit Packs,) you only need the DLC if you actually want to play as those factions and with those units. Whether that's a better deal than buying Emperor Edition and the DLCs separately will vary, so shop around. So basically it's Emperor Edition and three specific Paid DLCs. Spartan Edition is a physical copy only rerelease of Rome 2, available in a limited number of countries (believed to be those where digital distribution isn't as common.) It functionally replaces Rome II, so everyone who plays Rome II has Emperor Edition these days.) (Also it's a free update for anyone who had Rome II, or whoever buys an old disc copy of Rome II even now. 2 Unit Packs (Beasts of War, Daughters of Mars)Įmperor Edition is a rerelease that accompanied the Patch 15 Major Overhaul, rather than a Game of the Year edition.4 Campaign Packs (Caesar in Gaul, Hannibal at the Gates, Wrath of Sparta, Empire Divided).4 Culture Packs (Greek States, Nomadic Tribes, Pirates & Raiders, Black Seas Colonies).You'll also get Patches 16, 17 and 18/Power & Politics automatically downloaded when you install.Įmperor Edition does not contain the paid additional content, specifically: 6 Free DLC factions ( Pontus, Seleucid, Baktria, Armenia, Getae, Massilia).Imperator Augustus Free Campaign (10 playable factions in that.).Patches 1 - 15 (including the Patch 15/Emperor Edition major overhaul.).Rome II Base Game (8 playable factions, Rome, Carthage, Macedon, Iceni, Arverni, Suebi, Parthia, Egypt.). I would like to ask you what is the difference between Emperor Edition and for example Wrath of Sparta Edition? Will i get Emperor Edition after i buy Wrath of Sparta?Įmperor Edition contains the base game and all the free content, specifically: "We're signing up so many bands and artists, it's great. "We have specialists for each instrument."Īnd what's been the response from artists? "They love it," says Humphrey. "We do all of our own notation," says Humphrey. A little light bulb went on over my head…"Īlong with the cool track isolating, looping and speed-manipulation functions, Jammit also provides note-for-note transcriptions and tab. But the time I came back, the guitarist would have the part figured out. What I ended up doing was, I'd take a section, loop it, put it on a click track, maybe slow it down and walk out of the room. Sometimes they might not remember how they played certain parts. "I would be sitting with guitar players and we'd be going over demos that were two or three years old. And once they've got their smoking riffs and solos nailed, they can record them right along with the master.Īccording to record producer and Jammit CEO Scott Humphrey, the idea of the Jammit software came to him while working with artists in the studio. Players can navigate to whatever section of a song they like, loop and slow it down to as much as half-speed (without changing pitch). With Jammit, musicians are virtually able to become part of Rush, Dream Theater, the Foo Fighters, Nirvana and many, many more, as the software allows them to isolate guitar, bass, drums, keyboard or vocal tracks for intense examination. Selectable Audio Mute lets you tune in silence before launching into your next big solo.Released in 2011, Jammit is the revolutionary music software, available for iPad, iPhone, iPod Touch and Mac OS X desktop (a Windows version is coming), that can isolate individual audio tracks within original multi-track master recordings. Tap the tuning fork icon to display the built-in chromatic tuner. Playing at home or playing on stage, you should always sound your best. More tones than you could ever use included for free! (With plenty of award-winning guitar software under our belts, we think we know a thing or two about good interface design.)Īccess over 10,000 Mobile POD app presets designed by artists, Line 6 and other players, right on your iPhone or iPad. Each amp and stompbox was designed to deliver an exceptional user experience. Mobile POD app is simple and intuitive, just like the gear its based on. The great tone and included gear selection are worthy of any guitarists collection. Powerful POD app tone available for free on the App StoreSM. Inside Mobile POD app are Line 6 models of celebrated modern and vintage gear. Classic English combos, shredtastic high-gain half-stacks, lean n mean cleans and all the delays, mods, EQs, dynamics, reverbs and fuzz boxes you could want. Each one is fully tweakable for you to dial in the tones you need. The Mobile POD app is jam-packed with models of celebrated amps, stompbox effects, speaker cabinets and more. Join the loyal legion of POD device players who have found their tone (and plenty of others) inside POD. Today, countless guitarists rely on POD devices in their studio racks, in their live rigs and now in their Apple iPhone and iPad devices. A decade ago, the original fire-engine-red, kidney-bean-shaped processor hit the scene and forever revolutionized how guitarists perform and record. It's impossible to talk about modeling without talking about POD multi-effect. Transfer tracks recorded with Mobile In straight to your DAW and keep the music going. Recording guitar tracks with Mobile In means every take is a keeper, not a "scratch track" you wont have to record them over again to get better sound. Mobile In is the perfect guitar interface for GarageBand. Use Mobile In with GarageBand and other CoreAudio apps. Use Mobile In with your other CoreAudio guitar apps and hear how much better they sound! It supports up to 24-bit/48 kHz digital audio and its guitar input features 110 dB dynamic range. The Mobile In digital input interface features pro-quality audio specs for guitar tones that are exceptionally rich and clear. Quick Start Guide: Installing Photon Design FIMMWAVE via CADpass client Photon design, photonics, Research Subscription Quick Start Guide: Installing Photon Design OmniSim/CrystalWave via CADpass client Photon Design CrystalWave and OmniSim Design Tools Quick Start Guide: Installing OptiFDTD via CADpass clientĬircuit simulation, industry, OptiFDTD, optiwave, photonics, Research Subscription, VIE Refer to the Quick Start Guide for instructions.Įmbedded Systems, fpga, LabView, microelectronics, national instruments, Research Subscription After the installation, you will need to activate it through CMC’s license server. Note: You do not need a product serial number to download or install the tool. Quick Start Guide: Installing NI LabVIEW via CADpass client Luceda, photonics, Photonics Featured, Research Subscription Quick Start Guide: Installing Luceda IPKISS via CADpass client
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